BRCAssure: targeted testing for hereditary breast and ovarian cancer
Integrated Genetics’ BRCAssure is a genetic test for BRCA1 and BRCA2 mutations in individuals at increased risk for developing hereditary breast, ovarian, or other cancers based on their personal or family history.
Having this information can allow your physician to provide the appropriate additional screening and/or prevention options that could help reduce your risk of developing cancer.
The BRCAssure test requires only a sample of blood and filling out a family history questionnaire.
BRCAssure—Comprehensive BRCA1/2 analysis
Full sequencing of the BRCA1/2 genes, plus deletion/duplication analysis. May be used to assess the risk of carrying a BRCA1/2 mutation when the patient’s history suggests an increased risk for hereditary breast and ovarian cancer in the absence of a known familial mutation.
BRCAssure—Ashkenazi Jewish panel
Targeted analysis of the founder mutations found within the Ashkenazi Jewish population. May be used as a first line test for individuals of Ashkenazi Jewish descent; if negative, the option to run a Comprehensive BRCA1/2 Analysis is available.
BRCAssure—BRCA1 targeted analysis
Targeted sequencing for specific familial or known mutation(s) on the BRCA1 gene.
BRCAssure—BRCA2 targeted analysis
Targeted sequencing for specific familial or known mutation(s) on the BRCA2 gene.
Risk of cancer in individuals with a BRCA1 or BRCA2 mutation1
|Cancer Type||General population (no mutation)||Individuals with mutation|
15% (N. European origin)
|up to 30%||up to 39%|
Other testing options
In addition to hereditary cancer screening, we offer a range of tests for family planning: carrier screening for disorders such as cystic fibrosis; noninvasive prenatal testing (NIPT) and serum screening for conditions such as Down syndrome; and diagnostic testing options for post-pregnancy or further confirmation of screening tests.
- BRCA1. Genetics Home Reference. Available at: http://ghr.nlm.nih.gov/gene/BRCA1. Accessed September 15, 2017.
- BRCA2. Genetics Home Reference. Available at: http://ghr.nlm.nih.gov/gene/BRCA2. Accessed September 15, 2017.
- BRCA1 and BRCA2: Cancer risk and genetic testing. National Cancer Institute website. Available at: http://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet. Accessed September 15, 2017.
- Petrucelli N, Daly MB and Pal T. BRCA1- and BRCA2-associated hereditary breast and ovarian cancer. Gene Reviews®. Available at: http://www.ncbi.nlm.nih.gov/books/NBK1247. Accessed September 15, 2017.