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Insight into a Patient's Risk for Hereditary Cancer

Vistaseq®

Approximately five to ten percent of cancers are thought to be caused by mutations in genes that are associated with hereditary cancer syndromes.1

VistaSeq® hereditary cancer panels

  • Genetic mutations have been associated with more than 50 hereditary cancer syndromes.1

  • Patients with genetic mutations associated with a hereditary cancer syndrome are at a higher risk of developing certain types of cancer than the general population, and usually at an earlier age of onset than is typical.

  • Genetic testing can help determine whether a patient with a suspected personal or family history of cancer has an inherited gene mutation.

  • Genetic testing can also help identify family members at risk for developing cancers associated with a hereditary cancer syndrome. VistaSeq® hereditary cancer panels are multi-gene tests that detect inherited mutations in genes which have been associated with an increased risk of developing hereditary cancers.

VistaSeq® hereditary cancer panels are multi-gene tests that detect inherited mutations in genes which have been associated with an increased risk of developing hereditary cancers.

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VistaSeq Hereditary Cancer Tests by NGSTest CodeGenes
Hereditary Cancer - 27 multi-gene panel481220APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FAM175A, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PRKAR1A, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53.
Hereditary Cancer Panel without BRCA1/2 Genes481240APC, ATM, BARD1, BMPR1A, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FAM175A, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PRKAR1A, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53.
High/Moderate Risk Breast Cancer Panel481452ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11, TP53
Breast Cancer Panel481319ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHECK2, FAM175A, MRE11A, MUTYH, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53
Breast and GYN Cancer Panel481341ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2,EPCAM, FAM175A, FANCC, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53
GYN Cancer Panel481330BRCA1, BRCA2, CHEK2, EPCAM, MHL1, MSH2, MSH6, MUTYH, PMS2, PTEN, TP53
Lynch Syndrome Panel483543MLH1, MSH2, MSH6, PMS2, EPCAM
MLH1 Comprehensive Analysis483496MLH1
MSH2 Comprehensive Analysis483508MSH2
MSH6 Comprehensive Analysis483520MSH6
PMS2 Comprehensive Analysis483532PMS2
High Risk Colorectal Cancer Panel481352APC, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2
Colorectal Cancer Panel481363APC, ATM, AXIN2, BLM, BMPR1A, BRCA1, BRCA2, CDH1, CDKN2A, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
APC Comprehensive Analysis483484APC
Pancreatic Cancer Panel481385APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL
Prostate Cancer Panel483555ATM, BRCA1, BRCA2, CHEK2, HOXB13 (NGS only), MLH1, MSH2, MSH6, PALB2, PMS2
Endocrine Cancer Panel481374CDC73, MAX, MEN1, NF1, PRKAR1A, PTEN, RET, SDHB, SDHC, SDHD, TMEM127, TP53, VHL
MEN1 Comprehensive Analysis483460MEN1
RET Comprehensive Analysis483472RET
Brain / CNS / PNS Cancer Panel481386ALK, APC, MEN1, MLH1, MSH2, MSH6, NBN, NF1, NF2, PHOX2B, PTCH1, PMS2, RB1, SMARCB1, SUFU, TP53, VHL
Renal Cell Cancer Panel481407EPCAM, FH, FLCN, GPC3, MET, MITF (c.952G>A), MLH1, MSH2, MSH6, PTEN, PMS2, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL, WT1

Additional hereditary cancer testing options

BRCAssure: Patients with BRCA mutations are at increased risk for breast, ovarian, and other cancers. Knowing your patient’s BRCA mutation status may assist in development of tailored prevention and treatment strategies. For this reason, Integrated Genetics offers a suite of BRCAssure tests to meet patients’ varied needs. 

Mutation-specific sequencing: For family testing when a mutation has been specifically identified through one of our VistaSeq panels.

Additional Resources

Reference

  1. Genetic Testing for Hereditary Cancer Syndromes. National Cancer Institute. Available at: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-t.... Accessed September 15, 2017.