The first commercially available NIPT, MaterniT® 21 PLUS can screen for chromosomal abnormalities such as trisomies 21, 18, and 13, and screen for fetal sex.
It was also one of the first NIPTs to screen for clinically relevant microdeletions, sex chromosome aneuploidies, and trisomies 16 and 22.
This depth and breadth matters as these chromosomal abnormalities can impact any pregnancy, regardless of age or family history.
And MaterniT 21 PLUS does not exclude testing for pregnancies with twins, nor those involving egg donors and surrogates.
MaterniT 21 PLUS also offers choice with four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA. With choice in panels—and fetal sex optional—MaterniT 21 PLUS is the most flexible and customizable commercial NIPT available.
Compare versions in the table below.
| MaterniT 21 PLUS Core | MaterniT 21 PLUS + SCA | MaterniT 21 PLUS + ESS | MaterniT 21 PLUS + SCA + ESS | |
| Fetal sex (optional) | ||||
| Trisomy 21 (Down syndrome) | ||||
| Trisomy 18 (Edwards syndrome) | ||||
| Trisomy 13 (Patau syndrome) | ||||
| Sex chromosome aneuploidies | ||||
| 45,X (Turner syndrome) | ||||
| 47,XXY (Klinefelter syndrome) | ||||
| 47,XXX (Triple X syndrome) | ||||
| 47,XYY (XYY syndrome) | ||||
| Enhanced Sequencing Series (clinically relevant microdeletions and aneuploidies) | ||||
| 22q (DiGeorge syndrome) | ||||
| 5p (Cri-du-chat syndrome) | ||||
| 1p36 deletion syndrome | ||||
| 15q (Prader-Willi syndrome) | ||||
| 15q (Angelman syndrome) | ||||
| 11q (Jacobsen syndrome) | ||||
| 8q (Langer-Giedion syndrome) | ||||
| 4p (Wolf-Hirschhorn syndrome) | ||||
| Trisomy 16 | ||||
| Trisomy 22 | ||||
Additional NIPT options
- MaterniT GENOME: the only clinically validated genome-wide NIPT, screens all 23 chromosomes, reporting aneuploidies, large deletions and duplications greater than 7 MB in addition to select microdeletions; after more than 35,000 tests resulted, up to 29% of all positive findings could only be detected by MaterniT GENOME methodology as compared to other NIPT offerings.1 Learn more.
- informaSeq: Integrated Genetics’ legacy NIPT; an ideal fit for practices that want testing only for trisomies 21, 18, and 13, and optional testing for fetal sex, monosomy X, triple X, Klinefelter syndrome, and XXY, or Jacobs syndrome. Learn more.
Other testing options
In addition to NIPT, we also offer: serum screening; carrier screening, from comprehensive to single-gene; diagnostic testing that can be used on prenatal and products of conception (POC) samples, as well as pediatric, cord blood or adult samples; and hereditary cancer screening.
References
1. Internal data.