Mosaicism Ratio. Personalized information for patients with positive NIPT results.
The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.10
When your current NIPT is not enough, use MaterniT 21 PLUS, the most clinically complete NIPT solution.1-4
Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.
Integrated Genetics has run over 1 million non-invasive prenatal tests (NIPT) since pioneering the technology in 2011, including more than 30,000 twins and more than 50,000 genome-wide tests;5 the depth of experience you should expect from an NIPT.
Now offering more screening options and flexibility than other NIPTs,1-4 including GENOME-Flex – the first NIPT high risk pathway – MaterniT 21 PLUS will deliver more value to your practice, and more service to your patients.
Each of the new features is designed to deliver a tangible positive benefit to you and your patients, while improving the service levels you should expect from an NIPT laboratory.
Maternit 21 Plus - New Features
Clear results with PPV and FF
Clear results with PPV and FF
MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.
Click here to view a sample MaterniT 21 PLUS report.
Services
Patient Engagement Program
Genetics is complex; understanding pricing options doesn’t need to be
We work directly with your patients to make our pricing options transparent
With our new Patient Engagement Program, your choice of a genetic testing partner is clear
New cost estimator plus rapid, proactive support from our expert Every Mom Pledge team
Patient responsibility was $0 for over 74% of patients6
New program provides $299 price for MaterniT® 21 PLUS, informaSeq® and Inheritest® NGS for qualifying patients
Send your patients to integratedgenetics.com/transparency or call 844.799.3243
SOCIETY GUIDELINES Professional societies like ACOG, ACMG, and SMFM endorse and/or recognize NIPT as a screening option for all pregnant women
| MaterniT® GENOME | MaterniT® 21 Plus | Other NIPTs** | |
|---|---|---|---|
| Trisomy 13, 18, 21 | |||
| Fetal sex | |||
| Sex chromosome aneuploidies | |||
| Microdeletions | |||
| Trisomy 16, 22 | |||
| GENOME-Flex high risk pathway | |||
| Genome-wide with subchromosomal CNVs |
*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test5 by Roche
MaterniT® 21 PLUS customizable screening options and capabilities
MaterniT 21 PLUS also offers choice with four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA. With choice in panels— and fetal sex optional— MaterniT 21 PLUS is the most flexible and customizable commercial NIPT available.
Compare versions in the table below.
| MaterniT 21 PLUS Core | MaterniT 21 PLUS + SCA | MaterniT 21 PLUS + ESS | MaterniT 21 PLUS + SCA + ESS | GENOME-Flex (Add On) | GENOME-Flex (Add On) Redraw | |
|---|---|---|---|---|---|---|
| Fetal sex (optional) | ||||||
| Singleton Pregnancies (Only) | ||||||
| Twin & Multiple Pregnancies | ||||||
| Trisomy 21 (Down syndrome) | ||||||
| Trisomy 18 (Edwards syndrome) | ||||||
| Trisomy 13 (Patau syndrome) | ||||||
| SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only) | ||||||
| 45,X (Turner syndrome) | ||||||
| 47,XXY (Klinefelter syndrome) | ||||||
| 47,XXX (Triple X syndrome) | ||||||
| 47,XYY (XYY syndrome) | ||||||
| ENHANCED SEQUENCING SERIES (CLINICALLY RELEVANT MICRODELETIONS AND ANEUPLOIDIES) | ||||||
| 22q (DiGeorge syndrome) | ||||||
| 5p (Cri-du-chat syndrome) | ||||||
| 1p36 deletion syndrome | ||||||
| 15q (Prader-Willi syndrome) | ||||||
| 15q (Angelman syndrome) | ||||||
| 11q (Jacobsen syndrome) | ||||||
| 8q (Langer-Giedion syndrome) | ||||||
| 4p (Wolf-Hirschhorn syndrome) | ||||||
| Trisomy 16 | ||||||
| Trisomy 22 | ||||||
| MaterniT GENOME - GENOME-WIDE SCREENING | ||||||
| Genome-wide with subchromosomal CNVs | ||||||
| TAT | ||||||
| Turn Around Time | 3-5 days | 3-5 days | 3-5 days | 3-5 days | 72 hours | 72 hours |
| SPECIMEN COLLECTION GESTATIONAL AGE - 9 WEEKS | ||||||
| 9 Weeks Gestational Age | ||||||
MaterniT specimen collection kit
The MaterniT specimen collection kit features new branding for better kit identification and fewer components – including one 10 mL Streck tube instead of two – for improved ease of use.
If you’ve not had a test and have questions about costs or coverage, use our estimator.
If you have already had a test performed, we can help answer questions about results.
Ask questions about genetic testing options or results, or schedule an appointment.
References
- Illumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/verifi-pr.... Accessed August 15, 2018.
- Natera. https://www.natera.com/panorama-test/clinical-information. Accessed August 15, 2018.
- Counsyl. https://www.counsyl.com/services/prelude/clinical-info. Accessed August 15, 2018.
- Progenity. https://progenity.com/tests/innatal. Accessed August 15, 2018.
- Harmony. https://www.harmonytestusa.com/healthcare-professionals/providing-harmony. Accessed August 15, 2018.
- Internal data
- Internal data
- Palomaki GE, Deciu C, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet Med. 2011;13(11):913-920.
- Wardrop J, McCullough R, Boomer T, et al. Maternal weight – impact on noninvasive prenatal testing (NIPT). Clinical poster presented at ACMG annual meeting, Florida 2016.
- Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.