mother kissing infant

MaterniT® 21 plus

Your patients deserve more, so you should expect more from a NIPS (NIPT)

Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.

Proven performance in twin pregnancies

Despite overall limited data on cell-free DNA (cfDNA) testing in twin gestations, MaterniT 21 PLUS has demonstrated high sensitivity and specificity in screening for trisomy 21 in twins from the first trimester of pregnancy (comparable to that observed in singleton pregnancies), as well as promising performance in screening for trisomies 13 and 18, according to the results of a newly published study.1 Hear from our experts about the nuances of twin pregnancy care as we combine ultrasound expertise with the latest research review on fetal cfDNA screening.

 

Use MaterniT 21 PLUS, the most clinically complete cfDNA solution.2-6

Labcorp has run over 3 million noninvasive prenatal screening  tests since pioneering the technology in 2011, including more than 60,000 twins and more than 135,000 genome-wide tests.7 With high sensitivity and specificity observed in both singleton and twin gestations in a newly published study1, MaterniT 21 PLUS provides timely, effective results to you and your patients. 

MaterniT 21 PLUS has more screening options and flexibility than other cfDNA prenatal tests,2-6 including GENOME-Flex—the first cfDNA high risk pathway. Each of the features is designed to deliver more value to your practice, tangible positive benefit to your patients and overall higher service levels expected from a cfDNA laboratory.
 

Mosaicism Ratio.

Mosaicism Ratio

Personalized information for
patients with positive NIPS (NIPT) results.

The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.8

Learn more

MaterniT 21 PLUS Features

A new NIPS (NIPT) high risk pathway

Genome-Flex

The only clinically validated genome-wide NIPS (NIPT), screens all 23 chromosome pairs, reporting aneuploidies, large deletions and duplications greater than 7 Mb in addition to select microdeletions

Learn more about Genome-Flex

 MaterniT® GENOMEMaterniT® 21 PlusOther NIPSs (NIPTs)**
Trisomy 13, 18, 21
Yes
Yes
Yes
Fetal sex*
Yes
Yes
Yes
Sex chromosome aneuploidies
Yes
Yes
Yes
Microdeletions
Yes
Yes
Yes
Trisomy 16, 22
Yes
Yes
 
GENOME-Flex high risk pathway
Yes
Yes
 
Genome-wide with subchromosomal CNVs
Yes
  

*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test6 by Roche

Clear results with PPV and FF

MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.

Rapid results, earlier in pregnancy

Low non-reportable results & fewer patient redraws

Sample Report

MaterniT 21 PLUS customizable screening options and capabilities

  • Choice of four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA
  • Proven performance: MaterniT 21 PLUS has shown high sensitivity and specificity in screening for trisomies 13, 18 and 21 in singleton gestations, as well as for trisomy 21 in twin gestations (in a newly published study)1

With choice in panels—and fetal sex optional—MaterniT 21 PLUS is the most flexible and customizable commercial cfDNA test available across singleton pregnancies and twin pregnancies where applicable.

Compare versions in the table below.

 MaterniT 21 PLUS CoreMaterniT 21 PLUS + SCAMaterniT 21 PLUS + ESSMaterniT 21 PLUS + SCA + ESSGENOME-Flex (Add On)GENOME-Flex (Add On) Redraw
Fetal sex (optional)
Yes
Yes
Yes
Yes
Yes
Yes
Singleton Pregnancies (Only)
Yes
Yes
Yes
Yes
Yes
Yes
Twin & Multiple Pregnancies
Yes
 
Yes
   
Trisomy 21 (Down syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
Trisomy 18 (Edwards syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
Trisomy 13 (Patau syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only)
45,X (Turner syndrome) 
Yes
 
Yes
Yes
Yes
47,XXY (Klinefelter syndrome) 
Yes
 
Yes
Yes
Yes
47,XXX (Triple X syndrome) 
Yes
 
Yes
Yes
Yes
47,XYY (XYY syndrome) 
Yes
 
Yes
Yes
Yes
ENHANCED SEQUENCING SERIES (CLINICALLY RELEVANT MICRODELETIONS AND ANEUPLOIDIES)
22q (DiGeorge syndrome)  
Yes
Yes
Yes
Yes
5p (Cri-du-chat syndrome)  
Yes
Yes
Yes
Yes
1p36 deletion syndrome  
Yes
Yes
Yes
Yes
15q (Prader-Willi syndrome)  
Yes
Yes
Yes
Yes
15q (Angelman syndrome)  
Yes
Yes
Yes
Yes
11q (Jacobsen syndrome)  
Yes
Yes
Yes
Yes
8q (Langer-Giedion syndrome)  
Yes
Yes
Yes
Yes
4p (Wolf-Hirschhorn syndrome)  
Yes
Yes
Yes
Yes
Trisomy 16  
Yes
Yes
Yes
Yes
Trisomy 22  
Yes
Yes
Yes
Yes
MaterniT GENOME - GENOME-WIDE SCREENING
Genome-wide with subchromosomal CNVs    
Yes
Yes
TAT
Turn Around Time3-5 days3-5 days3-5 days3-5 days72 hours72 hours
SPECIMEN COLLECTION GESTATIONAL AGE - 9 WEEKS
9 Weeks Gestational Age
Yes
Yes
Yes
Yes
Yes
Yes
MaterniT specimen collection kit for clients, PSCs, IOPs: FedEx clinical pak included

MaterniT specimen collection kit

Starting in July 2023, we are updating our MaterniT cfDNA specimen collection kits with a new look to help increase understanding that MaterniT is a screening test. The kit components and specimen collection requirements will not change.

Download Flyer

Additional Resources

References

  1. Dugoff L, Koelper NC, Chasen ST, et al. Cell-free DNA screening for trisomy 21 in twin pregnancy: a large multicenter cohort study. Am. J. Obstet. Gynecol. 2023. doi:10.1016/j.ajog.2023.04.002.
  2. Illumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/verifi-pr.... Accessed August 15, 2018.
  3. Natera. https://www.natera.com/panorama-test/clinical-information. Accessed August 15, 2018.
  4. Counsyl. https://www.counsyl.com/services/prelude/clinical-info. Accessed August 15, 2018.
  5. Progenity. https://progenity.com/tests/innatal. Accessed August 15, 2018.
  6. Harmony. https://www.harmonytestusa.com/healthcare-professionals/providing-harmony. Accessed August 15, 2018.
  7. Internal data
  8. Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.