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Tay-Sachs disease is an autosomal recessive disease most common in individuals of Eastern European Jewish, French Canadian, or Cajun descent. Tay-Sachs disease causes deterioration in both mental and physical abilities. Individuals with Tay-Sachs disease usually die by age 5. A less common form affects adults rather than children. At this time there is no treatment for Tay-Sachs disease. View testing options