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Afp4® Screening - Quadruple Marker Test (AFP, hCG, uE3, Inhibin A)

CPT:

82105; 82677; 84702; 86336


Synonyms

AFP Tetra; Alpha-Fetoprotein (AFP) Tetra Profile;


Test Includes

α-Fetoprotein, serum; dimeric inhibin A (DIA); human chorionic gonadotropin (hCG); unconjugated estriol (uE3)


Special Instructions

Please Note: Ultrasound BPD (biparietal diameter) dating of pregnancy is preferred for optimal accuracy of risk calculations.



Specimen Requirements


Specimen

Whole blood; serum


Volume

Serum: 2-3 mL (unhemolyzed).
Whole Blood:  7 mL in SST or 10 ml in red-top tube; allow to clot; centrifuge (15 minutes at 1,000 g) to prevent hemolysis.


Container

Serum:  AFP tube 
Whole Blood:  Serum separator tube (SST) or red-top tube.


Collection

Avoid hemolysis. Send complete specimen in the original tube. Do not pour off.


Storage Instructions

Maintain at room temperature


Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis


Test Details


Use

Screening test for open neural tube defects (detects 80% open spina bifida, 90% anencephaly), Down syndrome (detects 75% to 80%), and trisomy 18 (detects 73%)


Methodology

Immunochemiluminometric assay (ICMA)


Pregnancy Week

14–21 Weeks

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