LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.

Cytogenetics Amniotic Fluid Chromosome Analysis


88235; 88269; 88280; 88285

Amniotic fluid chromosome analysis is recommended to be offered to all pregnant women by The American College of Obstetricians and Gynecologists (ACOG) for diagnostic testing (as opposed to just screening) for chromosome abnormalities   Additional specific indications  cytogenetic analysis include: abnormal maternal serum screening results, abnormalities seen on ultrasound, family history of a chromosome abnormality, or known parental balanced chromosome rearrangement. 

Test Details


Determine fetal karyotype.



Test Includes

15-20 mitotic spreads counted from separate in situ colonies and 2 banded karyotypes prepared

Discipline Code

CG (Cytogenetics)

Specimen Requirements


Amniotic fluid


20-30 mL (15-20 mL for early amniocentesis)


Two 15 mL sterile orange-top tubes


Discard first 2 mL; then 15-25 mL amniotic fluid (less if early amniocentesis)

Special Instructions

Please call our Client Services Department prior to sending first specimen. If additional testing such as DNA is indicated, call Client Services for further specimen requirements.

Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; unlabeled or mislabeled specimen)

Storage Instructions

Maintain specimen at room temperature. Do not freeze.

Additional Information




If you’re a healthcare provider, you’re in the right place. If you’re a current or future patient, click the link below.