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Cytogenetics Amniotic Fluid Chromosome Analysis

CPT:

88235; 88269; 88280; 88285

Amniotic fluid chromosome analysis is recommended to be offered to all pregnant women by The American College of Obstetricians and Gynecologists (ACOG) for diagnostic testing (as opposed to just screening) for chromosome abnormalities   Additional specific indications  cytogenetic analysis include: abnormal maternal serum screening results, abnormalities seen on ultrasound, family history of a chromosome abnormality, or known parental balanced chromosome rearrangement. 

Test Details

Use

Determine fetal karyotype.

Synonyms

Karyotype

Test Includes

15-20 mitotic spreads counted from separate in situ colonies and 2 banded karyotypes prepared

Discipline Code

CG (Cytogenetics)

Specimen Requirements

Specimen

Amniotic fluid

Volume

20-30 mL (15-20 mL for early amniocentesis)

Container

Two 15 mL sterile orange-top tubes

Collection

Discard first 2 mL; then 15-25 mL amniotic fluid (less if early amniocentesis)

Special Instructions

Please call our Client Services Department prior to sending first specimen. If additional testing such as DNA is indicated, call Client Services for further specimen requirements.

Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; unlabeled or mislabeled specimen)

Storage Instructions

Maintain specimen at room temperature. Do not freeze.

Additional Information

Limitations

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