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FirstScreen® – First Trimester Screening

CPT:

84163; 84702

FirstScreen screens for fetal Down syndrome and trisomy 18 between 10 weeks/3 days and 13 weeks/6 days (10.4-13.9 weeks, CRL = 39-84 mm). Two biochemical markers, pregnancy associated plasma protein (PAPP-A) and human chorionic gonadotropin (hCG), and the nuchal translucency (NT) ultrasound measurement are combined to provide a risk assessment in the first trimester.

Test Details

Use

FirstScreen screens for fetal Down syndrome and trisomy 18 between 10 weeks/3 days and 13 weeks/6 days (10.4-13.9 weeks, CRL = 38-84 mm). Two biochemical markers, pregnancy associated plasma protein (PAPP-A) and human chorionic gonadotropin (hCG), and the nuchal translucency (NT) ultrasound measurement are combined to provide a risk assessment in the first trimester.

Pregnancy Week

0–13 Weeks

Specimen Requirements

Specimen

Whole blood, serum, or dried blood spot

Volume

Blood: 7-10 mL; Serum: 2-3 mL (unhemolyzed); Dried blood spot: minimum 3 circles

Container

Blood: Serum separator tube (SST) or red-top tube; Serum: Serum separator tube (SST); Dried blood spot: IG-Provided blood spot card

Collection

Blood: Allow to clot; centrifuge (15 minutes at 1000 g) to prevent hemolysis. Dried blood spot: If prenatal carrier screening for cystic fibrosis is ordered in conjunction with first trimester screening, all 6 circles should be filled.

Special Instructions

Integrated Genetics will only accept NT measurements from sonographers who have been certified by the Fetal Medicine Foundation (FMF) or the Nuchal Translucency Quality Review Program (NTQR). Please submit certification information before sending specimens for FirstScreen. Please contact our Client Services Department with any questions.

Additional Information

Limitations

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