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Maternal Cell Contamination Analysis (In-House Samples Only)



Integrated Genetics requires a maternal blood sample to conduct maternal cell contamination testing in conjunction with all prenatal molecular testing. Both amniotic fluid and CVS may have maternal cells present in the sample. These do not usually interfere with the accuracy of chromosome analysis, but are well-recognized as a potential source of error in molecular diagnosis. Integrated Genetics requires a maternal sample in order to provide maximal accuracy in prenatal molecular testing conducted in our laboratory.

Test Details


Analysis of short tandem repeat markers by polymerase chain reaction (PCR) and capillary electrophoresis

Pregnancy Week

0–13 Weeks
14–21 Weeks
22+ Weeks

Specimen Requirements


Whole blood or mouthwash (see specimen kit for detailed instructions)


Adults: 10 mL whole blood or mouthwash.


Lavender-top (EDTA) tube or yellow-top (ACD-A) tube or mouthwash kit


Mouthwash collection:  Patient should not eat, drink, smoke or chew gum for at least one hour prior to collection. (See specimen kit for detailed instructions). 

Mouthwash samples can be sent when ordering up to two tests. When ordering more than two tests, blood samples are required.  10 mL of Scope® mouthwash that has been swished vigorously for at least 1 minute. Collect in orange-top 50 mL polypropylene tube. 

Special Instructions

A maternal blood sample is required to rule out the presence of maternal cells in prenatal samples of uncultured amniotic fluid, CVS, or CVS cultures.

Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; unlabeled or mislabeled specimen


Storage Instructions

Maintain specimen at room temperature

Additional Information


False positive or false negative results may occur for reasons that include: genetic variants, technical handling, blood transfusions, bone marrow transplantation, mislabeling of samples, or erroneous representation of family relationships



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