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Maternal Serum Alpha-Fetoprotein (MSAFP)

CPT:

82105

MSAFP is a single marker screening test performed on a maternal serum sample collected in the second trimester between 15 weeks / 0 days and 23 weeks / 6 days (15.0 - 23.9 weeks). The results provide a risk assessment for fetal open neural tube defects. It is appropriate to order this test following CVS or first trimester screening for fetal Down syndrome, as these analyses do not screen for open neural tube defects.

Test Details

Use

Risk assessment for fetal open neural tube defects.

Synonyms

AFP, Maternal Serum; Alpha-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida; Maternal Serum α-Fetoprotein; msAFP;

Methodology

Immunochemiluminometric assay (ICMA)

Pregnancy Week

14–21 Weeks
22+ Weeks

Specimen Requirements

Specimen

Whole blood or serum (unhemolyzed

Volume

Serum: 2-3 mL

Whole Blood: 7 mL

Container

Serum: AFP tube

Whole Blood: Serum separator tube (SST) or red-top tube

Collection

Whole Blood:  allow to clot; centrifuge (15 minutes at 1,500 rpm) to prevent hemolysis.

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis

Storage Instructions

Refrigerate.

Additional Information

Limitations

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