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Maternal Serum Alpha-Fetoprotein (MSAFP)

CPT:

82105


Synonyms

AFP, Maternal Serum; Alpha-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida; Maternal Serum α-Fetoprotein; msAFP;



Specimen Requirements


Specimen

Whole blood or serum (unhemolyzed


Volume

Serum: 2-3 mL

Whole Blood: 7 mL


Container

Serum: AFP tube

Whole Blood: Serum separator tube (SST) or red-top tube


Collection

Whole Blood:  allow to clot; centrifuge (15 minutes at 1,500 rpm) to prevent hemolysis.


Storage Instructions

Refrigerate.


Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis


Test Details


Use

Risk assessment for fetal open neural tube defects.


Methodology

Immunochemiluminometric assay (ICMA)


Pregnancy Week

14–21 Weeks
22+ Weeks

Patient?

Patient?

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