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Reveal® SNP Microarray – POC

CPT:

81229


Special Instructions



Specimen Requirements


Specimen

Preferred nonfixed tissue or products of conception (POC)/placental villus biopsy; formalin-fixed paraffin-embedded tissue; (Samples received in fixative are subject to additional charge for histopathology processing and reporting); unstained tissue slides


Volume

>2-4 mm3 tissue


Container

Sterile container containing transport media provided by our laboratory, Ringer's lactate, or Hanks' balanced salt solution


Collection

Aseptically obtain a small piece of fetal tissue that does not appear necrotic. If specimen is a POC, placental villi or membranes may be the only fetal-derived tissue available, and an effort should be made to submit these tissues rather than maternal decidua.


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Quantity not sufficient for analysis; necrotic tissue submitted


Test Details


Use

Detects chromosomal imbalance that may be associated with fetal loss and is ideal for detection of complete or partial moles


Limitations

Unable to determine genotypes on some formalin-fixed tissue (blocks/slides), allowing only genomic dosage to be determined. This assay does not detect balanced rearrangements, low-level mosaicism (<10%), or tetraploidy.


Methodology

Whole genome SNP-based copy-number microarray analysis targeting 2.695 million copy-number and allele-specific genome sites


References

Coppinger J, Alliman S, Lamb A, et al. Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray. Prenatal Diagn. 2009 Dec; 29(12):1156-1166.PubMed 19795450


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