Y Chromosome Microdeletion Analysis
Lavender-top (EDTA) tube or yellow-top (ACD-A) tube
Maintain specimen at room temperature.
Causes for Rejection
Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; unlabeled or mislabeled specimen
This test detects microdeletions in three azoospermia factor chromosome regions (Yq11.23) that contain genes with a role in spermatogenesis. Deletions of all or part of these regions, designated AZFa, AZFb, and AZFc, cause variable clinical symptoms in 5% to 13% of infertile men, ranging from azoospermia and Sertoli cell-only syndrome to severe or mild oligospermia.
False-positive and false-negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, erroneous representation of family relationships, or contamination of a fetal sample with maternal cells.