Y Chromosome Microdeletion Analysis

CPT:

81479 

Updated on 12/11/2019


Specimen Requirements


Specimen

Whole blood


Volume

20 mL 


Container

Lavender-top (EDTA) tube or yellow-top (ACD-A) tube


Collection

 

 


Storage Instructions

 Maintain specimen at room temperature.


Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; unlabeled or mislabeled specimen


Test Details


Use

This test detects microdeletions in three azoospermia factor chromosome regions (Yq11.23) that contain genes with a role in spermatogenesis. Deletions of all or part of these regions, designated AZFa, AZFb, and AZFc, cause variable clinical symptoms in 5% to 13% of infertile men, ranging from azoospermia and Sertoli cell-only syndrome to severe or mild oligospermia. 


Limitations

False-positive and false-negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, erroneous representation of family relationships, or contamination of a fetal sample with maternal cells.


Pregnancy Week

0–13 Weeks
14–21 Weeks
22+ Weeks

Patient?

Patient?

If you’re a healthcare provider, you’re in the right place. If you’re a current or future patient, click the link below.