LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.




Special Instructions

Blood:Whole:  allow to clot, centrifuge (15 minutes at 1,500 rpm) to prevent hemolysis.

Dried Blood Spot:  Please Note: Only the first trimester integrated sample (Part 1 of SerumIntegratedScreen) can be collected on dried blood spot filter paper. For the second trimester sample of SerumIntegratedScreen, please send whole blood or serum (see specimen requirements listed). Second trimester dried blood spot samples will be rejected and cancelled. Please Note: Please do not send dried blood spot samples for second trimester samples of SerumIntegratedScreen.

Specimen Requirements


Serum; whole blood, or dried blood spot


Serum:  2 mL serum, in SST for both first and second trimester specimens.

Whole Blood:  7 mL in SST or 10 mL in red-top tube for both first and second trimester specimens.

Dried Blood Spot: fill a minimum of three circles completely with blood. Please Note: If prenatal carrier screening for cystic fibrosis is ordered in conjunction with first trimester screening all six circles should be filled.


Serum: Serum separator tube (SST)

Whole Blood: Serum separator tube (SST) or red-top tube

Dried Blood Spots collected on Integrated Genetics provided filter paper/test requisition.


Avoid hemolysis. Send complete specimen in the original tube. Do not pour off.

Storage Instructions

Store at room temperature

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Test Details


Screening test for open neural tube defects, Down syndrome, and trisomy 18


SerumIntegratedScreen requires two specimens: one collected in the first trimester and one in the second trimester. This test is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine whether a neural tube defect or chromosome abnormality is present.


Enzyme immunoassay (EIA)

Pregnancy Week

0–13 Weeks
14–21 Weeks



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