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Genetic testing for miscarriage and pregnancy loss

According to the March of Dimes, “about 10 to 15 out of 100 pregnancies end in miscarriage… [but] As many as half of all pregnancies may end in miscarriage—we don’t know the exact number because many may happen before a woman knows she’s pregnant.”                 

Even though miscarriage is common, this fact does not reduce the emotional impact it can have. If you have recently experienced a miscarriage (within the first 20 weeks of a pregnancy) or a pregnancy loss (after 20 weeks), support groups, both online and off, can often provide comfort and encouragement.

While there are many causes of a pregnancy loss, the most common reason is an abnormal number of chromosomes present at fertilization.2,3

Pregnancy loss may also be caused by changes in the amount or structure of DNA–something that may also cause intellectual disabilities, certain birth defects, and autism spectrum disorders.4,5

Genetic counseling can also help you better understand genetic conditions that may impact a past, current, or future pregnancy, and counselors can explain test results as well. With the largest commercial network of genetic counselors in the US, we’re doing all we can to ensure you get all the support you may need. Learn more.

Reveal

Reveal

The Reveal®​ SNP Microarray POC (products of conception) test offered by Integrated Genetics may help you to understand why your pregnancy loss occurred and your potential risk in future pregnancies.

In some cases—and especially for those who have experienced more than one pregnancy loss—additional information may be found during the first trimester of a future pregnancy through testing such as NIPT.

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Ask questions about genetic testing options or results, or schedule an appointment.

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About your results

If you have already had a test performed, we can help answer questions about results.

References

  1. March of Dimes. Miscarriage. http://www.marchofdimes.org/complications/miscarriage.aspx. Accessed April 16, 2015.
  2. The American College of Obstetricians and Gynecologists. Frequently Asked Questions – Repeated Miscarriage, FAQ100. June 2013.
  3. The American College of Obstetricians and Gynecologists. Frequently Asked Questions – Early Pregnancy Loss, FAQ090. June 2013.
  4. McKinlay Gardner RJM, Sutherland GR. Elements of medical cytogenetics. In: McKinlay Gardner RD, Sutherland GR, eds. Chromosome Abnormalities and Genetic Counseling. 3rd ed. New York, NY: Oxford University Press; 2004:3-20.
  5. Rosenfeld J, et al. Development of an extensive array CGH database as a free resource for large scale collaborative research. Abstract presented at: Annual Clinical Genetics Meeting; March 25-29, 2009; Tampa, FL.