This Practice Bulletin was developed by the American College of obstetricians andGynecologists’Committee on Practice Bulletins—Obstetrics and Committee on Genetics, and the Society for Maternal-Fetal Medicine in collaborationwithNancy C. Rose,MD, and Anjali J.Kaimal, MD, MAS, with the assistance of Lorraine Dugoff, MD, and Mary E. Norton, MD, on behalf of the Society for Maternal-Fetal Medicine.

Qiandong Zeng, Natalia T. Leach, Zhaoqing Zhou, Hui Zhu, Jean A. Smith, Lynne S. Rosenblum, Angela Kenyon, Ruth A. Heim, Marcia Eisenberg, Stanley Letovsky & Patricia M. Okamoto

Samantha Caldwell, Katelynn Sagaser, Zoe Nelson, Jennifer Frey, Jenna Wardrop, Theresa Boomer, Ron McCullough, Stuart Schwartz

Jason Chibuk, Jill Rafalko, Theresa Boomer, Ron McCullough, Graham McLennan, Philip Wyatt, and Eyad Almasri

Margriet Johansen, MS, CGC; Christine Riordan, MS, CGC; Inder K. Gadi; PhD, FACMG; Peter R. Papenhausen; PhD, FACMG; Stuart Schwartz, PhD, FACMG. Laboratory Corporation of America®, Center for Molecular Biology and Pathology, Department of Cytogenetics, Research Triangle Park, NC

Stuart Schwartz, Inder Gadi, Andrea Penton, Karen Phillips, Hiba Risheg, Katie Rudd, Justin Schleede, James Tepperberg, Peter Papenhausen. Integrated Genetics, Laboratory Corporation of America®, Durham, NC

Kristi Fissell, Mary Badura, Jillian Carroll, Deborah Durand. Integrated Genetics, Laboratory Corporation of America®, Westborough, MA

Robert Wallerstein, MD; Kristi Fissell, MS. Integrated Genetics, Laboratory Corporation of America®, Westborough, MA

Sidra Boshes, Jenna Wardrop, Michelle Hackbardt, Samantha Caldwell, Theresa A. Boomer, Eyad Almasri, Ron McCullough. Sequenom Laboratories®, San Diego, CA/Laboratory Corporation of America®

Jenna Wardrop, Chen Xu, Eyad Almasri, Theresa Boomer, Sidra Boshes, Ron McCullough

Anna Victorine, MS, LCGC; Dagny Noeth, MS, CGC; Mary Hricik, MS, CGC; Elizabeth Lyon, MS, CGC; Alecia Willis, PhD; Melissa Hayden, PhD

Michelle Pierce Garcia, MS, CGC; Dr. Stuart Schwartz, PhD, FACMG; Laura Kline, MS, CGC; Jenny Shafer, MS, CGC; Elizabeth Lyon, MS, CGC; Merry Ferre, MS, CGC

Michelle Hackbardt, Samantha Caldwell, Jenna Wardrop, Sidra Boshes, Theresa Boomer, Eyad Almasri, Phil Cacheris, Ron McCullough

Jill Rafalko, MS, LCGC; Theresa Boomer, MS, CGC; Samantha Caldwell, MS, CGC; Jason Chibuk, MS, CGC

Kimberly Fanelli, MS, CGC; Samantha Caldwell, MS, CGC; Brittany Dyr, MS, CGC; Theresa Boomer, MS, CGC