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MaterniT 21 PLUS offers a very high success rate, especially in patients with higher maternal weight

A failed NIPT test result may lead to unnecessary patient redraws and/or diagnostic procedures, an issue often compounded by increasedmaternal weight. MaterniT 21 PLUS has a very high success rate inpatients with elevated maternal weight:

  • 97.6% in patients that weigh between 200-225 lbs1
  • 92.7% in patients that weigh 300+ lbs1

Some NIPTs have a success rate as low as 72.5% (27.5%corresponding failure rate) in patients weighing over 200 lbs.2

MaterniT Weight
Success

Highly reliable, extensively validated, the performance you should expect from the pioneer of NIPT

The MaterniT 21 PLUS test offers very low published and commercial non-reportable rates for trisomies 13, 18, and 21.

MaterniT Plus Graph

 

The MaterniT 21 PLUS test has been validated in clinical studies that tested samples from more than 2,100 pregnant women. The table below shows values for aneuploid samples in patients across four clinical studies, and accuracy for fetal sex within an additional publication.

Positive results
Positive results Sensitivity Specificity

210 of 212 - trisomy 213,4

210 of 212 - trisomy 213,4

99.1% 99.9%

59 of 59 - trisomy 184

59 of 59 - trisomy 184

> 99.9% 99.6%

11 of 12 - trisomy 134

11 of 12 - trisomy 134

91.7% 99.7%

8 of 8 multiple gestations: 7 of trisomy 21 | 1 of trisomy 138

8 of 8 multiple gestations: 7 of trisomy 21 | 1 of trisomy 138

> 99.9% detection rate

Fetal sex9

Fetal sex9

99.4% accuracy

25 of 26 combined sex chromosome aneuploidies10

25 of 26 combined sex chromosome aneuploidies10

96.2% 99.7%

In a high-risk group, MaterniT 21 PLUS showed a positive predictive value greater than 97.9% for trisomy 21.11

References

  1. Wardrop J, McCullough R, Boomer T, et al. Maternal weight – impact on noninvasive prenatal testing (NIPT). Clinical poster presented at ACMG annual meeting, Florida 2016.
  2. Dar P, Curnow KJ, Gross SJ, et al. Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing. Am J Obstet Gynecol. 2014 Nov; 211(5); 527.e1-527.e17.
  3. Palomaki GE, Deciu C, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet Med. 2011;13(11):913-920.
  4. Palomaki GE, Deciu C, Kloza EM, et al. DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13, as well as Down syndrome: An international collaborative study. Genet Med. 2012;14(3):296-305.
  5. Norton ME, Brar H, Weiss J, et al. Non-invasive chromosomal evaluation (NICE) study: results of a multicenter, prospective, study for detection of fetal trisomy 21 and trisomy 18. Am J Obstet Gynecol. 2012 Aug;207(2):137.e1-8.
  6. Bianchi DW, Platt LD, Goldberg JD, et al. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012 May;119(5):890-901.
  7. Pergament E, Cuckle H, Phil D, et al. Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort. Obstet Gynecol. 2014 August; 124(20 1): 210–218.
  8. Canick JA, Kloza EM, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations. Prenat Diagn. 2012 Aug;32(8):730-4.
  9. Mazloom, A, Oeth P, Wang T, et al. Accuracy of noninvasive prenatal sex determination using massively parallel sequencing in samples from a large clinical validation study. Poster presented at American Society of Human Genetics annual meeting; 2012 Nov 6-10; San Francisco, CA.
  10. Mazloom AR, Džakula Ž, Oeth P. et al. Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma. Prenat Diagn. 2013 Jun;33(6):591-7.
  11. Porreco RP, Garite TJ, Maurel K, et al. Noninvasive prenatal screening for fetal trisomies 21, 18, 13 and the common sex chromosome aneuploidies from maternal blood using massively parallel genomic sequencing of DNA. Am J Obstet Gynecol. 2014 Oct;211(4):365.e1-128.